In business, government, philanthropy, and the arts, and all over the globe, these men and women are transforming the world and inspiring others to do the same. Read more about our sixth annual listhere.

CEO; Senior Director, Strategy & Design for U.S. Benefits

Not Impossible Labs and Unreasonable Group (respectively)

and Steve Case and J.D. Vance, Rise of the Rest

Actor Michael J. Fox attends A Funny Thing Happened on the Way to Cure Parkinsons 2018 at the Hilton New York.

Parkinsons disease typically affects people when theyre around 60 years old. For star actor Michael J. Fox, it hit at 29. Fox was diagnosed in 1991 but didnt publicly reveal his disease until seven years later. That decision was fueled in part by a desire to raise awareness about Parkinsons and fund research to fight the degenerative disorder of the nervous system. Two decades later, Fox has become one of the most respected advocates in medicine.

His Michael J. Fox Foundation for Parkinsons Research, founded in 2000, has raised and invested some $900 million in the quest for a cure. Fox carries a deep belief that Parkinsons patients themselves must play a central role in curing the malady. Were the experts on what we have, he said in a recent Fortune interview. We have a responsibility as patientsif we expect [medical researchers] to do what we need them to do, they need to be fully informed on our experience, what works with us, what we respond to, what we can contribute.

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