In business, government, philanthropy, and the arts, and all over the globe, these men and women are transforming the world and inspiring others to do the same. Read more about our sixth annual listhere.

CEO; Senior Director, Strategy & Design for U.S. Benefits

Not Impossible Labs and Unreasonable Group (respectively)

and Steve Case and J.D. Vance, Rise of the Rest

In Manhiça, Mozambique in 2003. Melinda would sit on the ground, talking woman to woman about the things that mothers care about, recalls one ally who joined the trip. She has this remarkable ability to connect.

Courtesy of Bill & Melinda Gates Foundation/Barbara Kinney

For evidence of what happens when an unstoppable force Microsoftco-founder Bill Gates meets a profoundly movable human being, the empathetic Melinda Gates, one has simply to measure the impact of the Bill & Melinda Gates Foundation.

From January 1995 through the end of 2017, that namesake philanthropy (along with earlier Gates family foundations that were merged into the Bill & Melinda Gates Foundation in 2000) has deployed an extraordinary, barely countable $45.5 billion. That funding has launched, and then continually supported, what global health experts widely acknowledge to be some of the most successful international, private-public partnerships ever formed: GAVI, which has helped developing countries immunize 700 million children against preventable diseases. The second is The Global Fund to Fight AIDS, Tuberculosis and Malaria.

But the impact of Bill and Melinda Gates is due to more than money. As Warren Buffett toldFortune, The two of them have a multiplier effectthe two of them together. They act with a unity of purpose and with a difference of style.

ReadFortunes profile of Bill and Melinda Gateshere.

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